The Rabbit anti CSF-1R/M-CSFR Polyclonal antibody from MyBioSource.com is a Rabbit Polyclonal antibody to C-FMS, CD115, CSF1R, Csfmr, FIM2, FMS, M-CSF-R, and M-CSFR. This antibody recognizes Human, Mouse, Rat, and Bovine antigen. The Rabbit anti CSF-1R/M-CSFR Polyclonal antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
CD115, or Colony-stimulating factor-1 receptor (CSF-1R), is the major regulator of macrophage development and associated with epithelial cancers of the breast and ovary. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subquently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. The activated or phosphorylated form of CSF-1R has been associated with enhanced invasive and metastatic potential. The phosphorylation residues includeTyr 708, Tyr 723, Tyr 809 which correlate CSF-1R expression with changes in the growth and development of the cancer stage